Alpha-Fetoprotein







 WCCRB-2018

Being an Organizing Committee Member at 2nd World Congress on Clinical Research & Biomarkers Conference held by Scientific Federation is invited as Speaker for this conference. Vladimir N. Pak has completed his PhD from Moscow Institute of Bioorganic Chemistry, Russia and has over 30 years of post-doctoral experience in virology, immunology, biotechnology, pharmacology and oncology. He has published 7 patents related to API research and medicines manufacturing. He is the inventor of the anti-cancer medicines based on alpha-fetoprotein (AFP)-toxin non-covalent complexes that act as a targeted chemotherapy and MDSCs-immunotherapy. As a freelance researcher I need to know what kind of discount you can provide to me.



Alpha-fetoprotein (AFP) is a pregnancy biomarker. The protein shuttles essential nutrients to AFP receptor (AFPR)-positive embryonic cells. For majority of cancers AFPR is a biomarker and it is also expressed by host myeloid-derived suppressor cells (MDSCs).AFP delivers selected nutrients to MDSCs that suppress innate and adaptive immunity during cancer, inflammation, hemopoiesis and regeneration.AFP loaded with a medicine can be helpful in treating autoimmune diseases and inflammation, in transplantation, etc. On the other hand, AFP loaded with a toxin can destroy cancer cells and MDSCs. MDSCs depletion unleashes innate and adaptive immunity to remove cancer cells. In addition to traditional use as a pregnancy and tumor biomarker AFP obtains the new immunotherapy drug use.

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