Lymphoma



WCCRB-2018
Scientific Federation invites all the participants from all over the world to attend 2nd World Congress on Clinical Research & Biomarkers during September 17-18, 2018 Toronto, Canada. 
There are many number of Lymphoma in pathology few of them are
Malignant lymphoma mainly includes Non-Hodgkin’s lymphoma (NHL) and Hodgkin’s lymphoma (HL). Its incidence is increasing and now ranges among the tenth most frequent cancers worldwide.

Mantle cell lymphoma (MCL) is an aggressive B-NHL that arises from naïve B cells in the mantle zone of the lymph nodes. It is characterized by translocation and subsequent over expression of CCND1.

Methylation study in Mantle cell lymphoma cell lines found in different expressed genes mapped to autosomal chromosomes. Pathway analysis revealed that top cellular functions represented cell death, cell cycle, cellular growth and proliferation. Mass ARRAY assay of 25 candidate genes in seven MCL cell lines and normal B cells showed genes hyper ethylated in more than one MCL cell line, encompassing cell differentiation, cell adhesion, cell cycle and apoptosis p53 pathway and PI3K pathway, transcription factors and many unknown functions are there in MCL

Hodgkin’s lymphoma (HL) Screening of methylated genes was performed in HL KM-H2 cell line by microarray analysis before and after treatment with 5-aza-2’-deoxycitidine. Thirty tumor suppressive genes were identified, including genes in cellular adhesion, growth arrest p53 pathway and two transcription factors. Among them was further confirmed methylated and down-regulated in primary HL cells. Restoration of CADM1 expression in HL cells decreased cell survival and increased their sensitivity to apoptosis, demonstrating that IGSF4silencing by CpG methylation inhibited apoptosis in Reed-Sternberg cells, which was an important process in HL pathogenesis.

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